A multi-point temperature monitoring system based on single-chip microcomputer is designed to solve the shortcomings of traditional single-point wired control. The system includes the host and three slave modules. From machine using digital temperature sensor DS18B20 to test the temperature, the temperature signal is transmitted to MCU, MCU to temperature signal processing, the processed data to the wireless module nRF24L01, nRF24L01 module and then sends the data to the host, the host nRF24L01 after receiving the temperature signal, sent to the host MCU processing, control the LCD1602 display temperature, when the temperature more than upper and lower limit, the SCM will start peripheral circuit buzzer alarm. The actual test results show that the temperature error measured by the system is small, the system performance is good, the structure is simple, the stability is reliable, and it has good popularization value.