The limitation of bandwidth in the channel of drilling fluid, and the demanding for faster generation speed of the pressure wave signal about drilling fluid are two challenges to the transmission of data from the bottom of the well. Because of this, a novel pressure wave signal generator for drilling fluid with the employment of data compression is an effective way to overcome these difficulties. In this paper, the good quality of consecution of measured data, and the gentle trend of the values, provide the chance of conducting great compression to the date by using DPCM predictive coding methods. Experiments’ results approved that based on present hardware and facilities, the transmission speed will double distortion measure is also within a controllable range.