In order to highspeed parallel drive AM2301 singlebus digital temperature humidity sensor, the special driving logic circuit (IP core) had been designed with Verilog HDL hardware description language based on analysis of single bus communication timing and data verification algorithm of temperature and humidity sensor in this paper. Moreover, using the IP core to parallel drive 4way AM2301 single bus digital temperature and humidity sensor, the distributed temperature and humidity measurement system was composed, which realtime measurement data can been displayed on the LCD screen as character or graphically. The temperature and humidity measurement system not only had a perfect scalability of temperature and humidity sensor number, but also achieved the set temperature and humidity monitoring scope of the upper and lower limits, transfinite alarm, measurement data storage, historical data query and analysis, and other functions.