Power supply system in high energy physics experiments is an important part of the electronics readout system. In addition to, the characteristics of high energy physics experimentsrequest the power supply system that not only has the fundamental capacity of output voltage and current but also has the capacity of multichannel output, flexible structure, resisting a dose of radiation and low output noise.In view of this, this paper aims to design a masterslave power supply system with 16 output channels.The power supply system is consisted by two identical power board cascaded by differential Ⅰ2C bus, master and slave board are automaticallydefined by way of controller and power supply board connection.Each positive output channel haslatchup during power up, the output voltage current threshold setting and monitoring, overcurrent protection, and other functions.Test results show that the power supply system can realize the automatic identification of masterslave board, output voltage, output current and low output noise can meet the requirements of design.The power supply system has good application and reference value in the high physics experiments.