Aiming at the problem of complex electromagnetic environment and interference between different devices in largescale ship platform, the technology of RF interference cancellation is studied. The mathematical principle and system model of RF interference cancellation are analyzed, and the relationship between cancellation performance and amplitude error and phase error is analyzed. By analyzing the principle of adaptive filter and combining the characteristics of Xband radar of large ship platform, a kind of radio frequency interference cancellation technology is proposed. The scheme uses the least mean square error (LMS) algorithm to verify the feasibility of the cancellation scheme. The simulation results show that the cancellation ratio of the RF cancellation system can be up to about 40 db, and the high cancellation ratio can be achieved.