In order to solve the problem of single measurement type of reading instrument for dam safety monitoring, a new type of reading instrument for safety monitoring is designed, which can efficiently realize the multiplexing measurement of the two kinds of sensor signals, vibrating wire and differential resistance. It uses STM32F407VET6 as microprocessor, through vibrating wire signal acquisition, differential resistance signal acquisition, channel multiplexing, Bluetooth communication, power control, human-computer interaction and other unit modules, to realize sensor signal measurement, mode switching , measured value displaying and so on .The experimental data and results show that the designed readout can realize the multiplexing measurement of vibration wire sensor and differential resistance sensor, and its absolute error parameters meet the current standard requirements.