In view of D2D communication reuse cellular user spectrum can improve the system throughput and frequency utilization, a joint resource allocation scheme is designed to maximize the system throughput under system user communication quality, firstly designing a mode selection scheme based on throughput optimization, and then optimizing D2D users by hybrid grey Wolf optimization algorithm under the premise of known channel allocation vectors. The simulation results show that the proposed scheme can effectively improve the total system throughput by 20% and reduce the interference suffered by cellular users by 90% compared with other schemes, and can also improve the convergence effect and operation speed.