In order to improve the ability to monitor the emissions of atmospheric pollutants, and for the shortage of the traditional atmospheric environmental monitoring stations, such as the lack of distribution, the limited monitoring scope and the high cost, a design of multi-parameter environment wireless monitoring node based on STM32F103 microcontroller and LoRa is proposed. The ADC and the serial port with DMA function inside of the STM32F103 is used to collecte the data of 6 electrochemical gas sensors, GPS location data, PM2.5/PM10 particle concentration data, the temperature and humidity. The collected data is transmitted to the LoRa gateway through the LoRa wireless module and displayed on the terminal. Test results show that the node can monitor 6 kinds of gas concentration, PM2.5/PM10 particle concentration, temperature and humidity and travel path in real time, and the error is within the allowable range. The node combined with UAV or unmanned vehicle has the advantages of wide monitoring range, high detection efficiency, high mobility and low cost; and it provides a new technical means for environmental monitoring in real time.