This paper introduces the basic constitution and the engineering application research status of the bridge strain data acquisition system, from two aspects of hardware circuit and software program to describe the design scheme of the strain data acquisition system, the key technologies of the hardware design of the system is mainly studied. The power management system based on TP4056 and STC12C2052AD is proposed. A new bridge circuit wiring method based on the Wheatstone bridge is designed to detect the strain capacity in significant nodes of the bridge. Aiming at the problem that the system measurement accuracy is reduced when the strain capacity is to maximum but the actual output voltage is very small, signal processing circuit is designed. Experimental tests conducted on bridge show that the proposed system can improve the measurement accuracy and operate steady, verified the correctness and feasibility of the proposed method.