To deal with the problem of severe distortion of the output waveform caused by the interference between the dual channel arbitrary waveform generator, this paper based on the theory of broad level power integrity and signal integrity theory, uses the target impedance method to design the decoupling capacitor network, to make the power’s impedance meets our design in the whole pass band, and in a further step, to make the power supply noise control in the acceptable range. Using SI9000 Polar to design a reasonable structure and line width, the signal line can meet the requirement of controllable impedance transmission line. Using the simulation software Cadence Signity 16.6 to simulate the system, and then tested on the hardware platform, the test results show that the interference between two channels’ signal is solved, the quality of the waveform signal has been greatly improved.