According to the measurement precision deficiency of thermoelectric material resistivity and the great change of resistivity with temperature, the measurement circuit with high precision and wide range for resistance is designed by using TMS320F28027 as the core processor. The experimental proved that the reference voltage can be automatic adjusted and the system can automatic tracking the best output of reference voltage and sampling resistance. The measurement circuit is a valuable circuit for the thermoelectric material resistivity measurement with the characteristics of high precision, low voltage and wide range. The circuit can be used in other similar large range resistance measurements with a little improvement.