In view of the large and complex space-based network constellation composed of hundreds, thousands, or even tens of thousands of satellites, the ground-based measurement and control network alone cannot meet the problem of real-time satellite management and control, and the long-term deviation from the ground reference caused by the independent measurement and control of the constellation network alone ( Time and space benchmarks) and other risks, this paper comprehensively considers the advantages of ground-based measurement and control network and inter-satellite networking, and proposes a parallel system method for autonomous operation of large-scale networking constellations. Through the construction of a space-earth integrated parallel system, under the action of the ACP framework, a space-earth integrated parallel operation mechanism is formed with the network constellation autonomous processing as the main and the ground parallel system support as a supplement, so as to realize the large-scale network constellation autonomous control, autonomous observation, and autonomous processing And autonomous monitoring and other autonomous operation functions. The research results show that the method proposed in this paper has reference value in the autonomous operation of large and complex constellations.