The gesture recognition method based on surface electromyography and pattern recognition has a broad application prospect in the field of rehabilitation hand. In this paper, a hand gesture recognition method based on surface electromyography (sEMG) is proposed to predict 52 hand movements. In order to solve the problem that surface EMG signals are easily disturbed and improve the classification effect of surface EMG signals, TiCNN-DRSN network is proposed, whose main function is to better identify the noise and reduce the time for filtering the noise. Ti is a TiCNN network, in which convolutional kernel Dropout and minimal batch training are used to introduce training interference to the convolutional neural network and increase the generalization of the model; DRSN is a deep residual shrinkage network, which can effectively eliminate redundant signals in sEMG signals and reduce signal noise interference. TiCNN-DRSN has achieved high anti-noise and adaptive performance without any noise reduction pretreatment. The recognition rate of this model on Ninapro database reaches 97.43% 0.8%.